Optimizing Anti-inflammatory Activities of Arabica Coffee Ground (Coffea arabica L.) Nanoparticle Gel

Background: Arabica coffee ground nanoparticles gel is known to possess good physicochemical properties and high phenolic contents in which the phenolics are famous for their anti-inflammatory activities. Objectives: : This study aimed investigate activities of arabica on carrageenan-induced male mice 6 h. The positive control was commercial medicine (Voltaren gel), negative base gel. Methods: inflammatory inhibition determined by measuring edema volume foot using a plethysmometer. Anti-inflammatory were optimized Box-Behnken Design response surface methodology. Results: or foot. increase from first 180th min caused release inflammation mediator such as histamine, prostaglandins, bradykinins, serotonin tissue; meanwhile, at 240th min, experienced decrease due prostaglandins synthesis tissue. obtained results indicated that has average value 27.75%. optimum formulation 0.500% Carbopol 940, 0.400% triethanolamine, 2.313% nanoparticle, giving 29.360% 29.670% predicted experimental values, with 0.812 desirability value, respectively. Conclusions: design can be used determine optimal grounds inhibition.